USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PSA2_HUMAN USC-OGP 2-DE database:  PSA2_HUMAN PSA2_HUMAN General information about the entry View entry in simple text format Entry name PSA2_HUMAN Primary accession number P25787 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome subunit alpha type-2; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=Macropain subunit C3; AltName: Full=Multicatalytic endopeptidase complex subunit C3; AltName: Full=Proteasome component C3;. Gene name Name=PSMA2 Synonyms=HC3, PSC3 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1021: pI=6.77; Mw=24310 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1297: pI=7.02; Mw=24039 Cross-references UniProtKB/Swiss-Prot P25787; PSA2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSA2_HUMAN Primary accession number P25787 Secondary accession number(s) Q6ICS6 Q9BU45 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 184) Name and origin of the protein Description RecName: Full=Proteasome subunit alpha type-2; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=Macropain subunit C3; AltName: Full=Multicatalytic endopeptidase complex subunit C3; AltName: Full=Proteasome component C3; Gene name Name=PSMA2 Synonyms=HC3, PSC3 Encoded on Name=PSMA2; Synonyms=HC3, PSC3 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D00760; BAA00657.1; -; mRNA EMBL AK290654; BAF83343.1; -; mRNA EMBL CR450317; CAG29313.1; -; mRNA EMBL CH236951; EAL24005.1; -; Genomic_DNA EMBL CH471073; EAW94152.1; -; Genomic_DNA EMBL BC002900; AAH02900.2; -; mRNA EMBL BC047697; AAH47697.1; -; mRNA CCDS CCDS5467.1; -; . PIR S15970; SNHUC3; . RefSeq NP_002778.1; NM_002787.4; . UniGene Hs.333786; -; . PDB 4R3O; X-ray; 2.60 A; B/P=2-234 PDB 4R67; X-ray; 2.89 A; B/P/d/r=2-234 PDB 5A0Q; EM; 3.50 A; B/P=1-234 PDB 5GJQ; EM; 4.50 A; C/i=1-234 PDB 5GJR; EM; 3.50 A; C/i=1-234 PDB 5L4G; EM; 4.02 A; B/O=1-234 PDB 5LE5; X-ray; 1.80 A; A/O=1-234 PDB 5LEX; X-ray; 2.20 A; A/O=1-234 PDB 5LEY; X-ray; 1.90 A; A/O=1-234 PDB 5LEZ; X-ray; 2.19 A; A/O=1-234 PDB 5LF0; X-ray; 2.41 A; A/O=1-234 PDB 5LF1; X-ray; 2.00 A; A/O=1-234 PDB 5LF3; X-ray; 2.10 A; A/O=1-234 PDB 5LF4; X-ray; 1.99 A; A/O=1-234 PDB 5LF6; X-ray; 2.07 A; A/O=1-234 PDB 5LF7; X-ray; 2.00 A; A/O=1-234 PDB 5T0C; EM; 3.80 A; AH/BH=2-234 PDB 5T0G; EM; 4.40 A; H=2-234 PDB 5T0H; EM; 6.80 A; H=2-234 PDB 5T0I; EM; 8.00 A; H=2-234 PDB 5T0J; EM; 8.00 A; H=2-234 PDBsum 4R3O; -; . PDBsum 4R67; -; . PDBsum 5A0Q; -; . PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5LE5; -; . PDBsum 5LEX; -; . PDBsum 5LEY; -; . PDBsum 5LEZ; -; . PDBsum 5LF0; -; . PDBsum 5LF1; -; . PDBsum 5LF3; -; . PDBsum 5LF4; -; . PDBsum 5LF6; -; . PDBsum 5LF7; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P25787; -; . SMR P25787; -; . BioGrid 111656; 132; . DIP DIP-29364N; -; . IntAct P25787; 31; . MINT MINT-1178435; -; . STRING 9606.ENSP00000455744; -; . BindingDB P25787; -; . ChEMBL CHEMBL2364701; -; . MEROPS T01.972; -; . iPTMnet P25787; -; . PhosphoSitePlus P25787; -; . SwissPalm P25787; -; . BioMuta PSMA2; -; . DMDM 130850; -; . OGP P25787; -; . REPRODUCTION-2DPAGE IPI00219622; -; . EPD P25787; -; . MaxQB P25787; -; . PaxDb P25787; -; . PeptideAtlas P25787; -; . PRIDE P25787; -; . TopDownProteomics P25787; -; . DNASU 5683; -; . Ensembl ENST00000223321; ENSP00000223321; ENSG00000106588; . GeneID 5683; -; . KEGG hsa:5683; -; . UCSC uc003thy.5; human; . CTD 5683; -; . DisGeNET 5683; -; . GeneCards PSMA2; -; . HGNC HGNC:9531; PSMA2; . HPA HPA008188; -; . MIM 176842; gene; . neXtProt NX_P25787; -; . OpenTargets ENSG00000106588; -; . OpenTargets ENSG00000256646; -; . PharmGKB PA33876; -; . eggNOG KOG0181; Eukaryota; . eggNOG ENOG410XPQ8; LUCA; . GeneTree ENSGT00550000074870; -; . HOGENOM HOG000091085; -; . HOVERGEN HBG003005; -; . InParanoid P25787; -; . KO K02726; -; . OMA WKATALG; -; . OrthoDB EOG091G0GX6; -; . PhylomeDB P25787; -; . TreeFam TF106207; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . GeneWiki PSMA2; -; . GenomeRNAi 5683; -; . PRO PR:P25787; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000106588; -; . CleanEx HS_PSMA2; -; . ExpressionAtlas P25787; baseline and differential; . Genevisible P25787; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000932; C:P-body; ISS:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0005839; C:proteasome core complex; ISS:UniProtKB; . GO GO:0019773; C:proteasome core complex; alpha-subunit complex; IEA:InterPro GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0009615; P:response to virus; IEP:UniProtKB; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.60.20.10; -; 1; . InterPro IPR029055; Ntn_hydrolases_N; . InterPro IPR000426; Proteasome_asu_N; . InterPro IPR023332; Proteasome_suA-type; . InterPro IPR001353; Proteasome_sua/b; . Pfam PF00227; Proteasome; 1; . Pfam PF10584; Proteasome_A_N; 1; . SMART SM00948; Proteasome_A_N; 1; . SUPFAM SSF56235; SSF56235; 1; . PROSITE PS00388; PROTEASOME_ALPHA_1; 1; . PROSITE PS51475; PROTEASOME_ALPHA_2; 1; .

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